lookindex

Survodutide

Also known as BI 456906

It works in big trials, roughly in the same range as semaglutide, with a lot of stomach side effects. Nobody can legally sell it yet.

Information only. Not medical advice. Talk to a doctor before you start, stop or change anything.

What people claim

  • Burns liver and belly fat first
  • Weight loss without muscle loss
  • The next Ozempic

What the evidence shows

  • In SYNCHRONIZE-1, adults with obesity lost 12.2% to 13.0% of body weight over 76 weeks, against 5.4% on placebo, counting everyone who started.[1]
  • The placebo group lost more than expected, partly because some people who stopped placebo started other weight loss drugs.[2]
  • It also acts on the glucagon receptor. Sub-studies reported larger drops in liver and belly fat than weight loss alone would predict.[2]

Known risks

  • Stomach side effects affected 80.9% to 89.7% of people on survodutide, against 47.9% on placebo.[1]
  • Stomach side effects made 17.8% to 20.2% stop treatment, against 2.9% on placebo.[2]
  • Unapproved GLP-1 type products sold online have been linked to dosing errors and fakes.[3]

Reported side effects

Moderated user reports are not open yet, so nothing is shown here. They will be labelled as unverified personal accounts.

Legal status

A summary, not legal advice. Rules change, and sport bans are separate.

United States

Unapproved

Trials only. Not FDA approved.

United Kingdom

Unlicensed

No licensed medicine contains it.

Australia

Not approved

TGA says importing, advertising or supplying unapproved peptides is unlawful.[4]

European Union

Not authorised

No authorised medicine. National rules on possession and import differ.

Sources

  1. 1.Survodutide for the treatment of adults with obesity (SYNCHRONIZE-1)New England Journal of Medicine, 2026
  2. 2.Survodutide phase 3 data signal metabolic gains beyond weight lossAmerican Journal of Managed Care, 2026
  3. 3.FDA's concerns with unapproved GLP-1 drugs used for weight lossUS FDA
  4. 4.Importing, compounding and supplying unapproved peptide productsTGA Australia

Profile last checked 7 Nov 2026.